Koronavir\u00fcs\u00fcn t\u00fcm varyantlar\u0131n\u0131 etkisiz hale getiren antikor ke\u015ffedildi<\/p>\n\n\n\n
D\u00fcnya genelinde yakla\u015f\u0131k 7 milyon insan\u0131n \u00f6l\u00fcm\u00fcne neden olan koronavir\u00fcs yak\u0131n bir zamanda tarih olabilir. Bilim insanlar\u0131, Omicron da dahil olmak \u00fczere yeni tip koronavir\u00fcs\u00fcn bilinen t\u00fcm varyantlar\u0131n\u0131 etkisiz hale getirebilen son derece g\u00fc\u00e7l\u00fc antikorlar ke\u015ffetti. Ara\u015ft\u0131rmac\u0131lar, bu antikorlar\u0131n koronavir\u00fcs\u00fcn yan\u0131 s\u0131ra, di\u011fer hayvan koronavir\u00fcsleri ile de sava\u015fabildi\u011fini ve gelecekteki bir pandemiyi \u00f6nleyebilece\u011fini a\u00e7\u0131klad\u0131.<\/p>\n\n\n\n
Science Advances adl\u0131 bilimsel dergide yay\u0131mlanan \u00e7al\u0131\u015fmaya g\u00f6re uluslararas\u0131 bir ara\u015ft\u0131rmac\u0131 ekibi, Koronavir\u00fcse kar\u015f\u0131 a\u015f\u0131lanm\u0131\u015f olan iyile\u015fmi\u015f bir SARS hastas\u0131n\u0131n kan\u0131ndan al\u0131nan antikorlar\u0131 izole etti. <\/p>\n\n\n\n
\u00d6nceki Koronavir\u00fcs enfeksiyonu ve a\u015f\u0131laman\u0131n bu benzersiz kombinasyonu, test edilen neredeyse t\u00fcm ilgili Koronavir\u00fcsleri durdurabilen son derece geni\u015f ve g\u00fc\u00e7l\u00fc bir antikor yan\u0131t\u0131 olu\u015fturdu.<\/p>\n\n\n\n
Singapur’da yer alan Duke-NUS T\u0131p Fak\u00fcltesi Geli\u015fen Bula\u015f\u0131c\u0131 Hastal\u0131klar (EID) Program\u0131’nda d\u00fcnyaca \u00fcnl\u00fc bir yarasa vir\u00fcs\u00fc uzman\u0131 olan \u00e7al\u0131\u015fman\u0131n k\u0131demli yazar\u0131 Wang Linfa, \u015fu ifadeleri kulland\u0131: <\/p>\n\n\n\n
“T\u00dcM KORONAV\u0130R\u00dcSLER \u0130\u00c7\u0130N TEK B\u0130R A\u015eI M\u00dcMK\u00dcN OLAB\u0130L\u0130R”<\/p>\n\n\n\n
“Daha \u00f6nce onaylanm\u0131\u015f t\u00fcm monoklonal antikorlar yeni ortaya \u00e7\u0131kan Koronavir\u00fcs varyantlar\u0131na kar\u015f\u0131 etkinli\u011fini kaybetti\u011finden, y\u00fcksek riskli Koronavir\u00fcs hastalar\u0131n\u0131n tedavisi i\u00e7in tedavi edici monoklonal antikor eksikli\u011fini gidermeye \u00e7al\u0131\u015ft\u0131k. Bu \u00e7al\u0131\u015fma, insan ba\u011f\u0131\u015f\u0131kl\u0131k sistemini do\u011fru \u015fekilde ‘e\u011fitebildikleri’ takdirde pan-Koronavir\u00fcs a\u015f\u0131lar\u0131n\u0131n m\u00fcmk\u00fcn oldu\u011funa dair cesaret verici kan\u0131tlar sunuyor.”<\/p>\n\n\n\n
\u00c7al\u0131\u015fma, ara\u015ft\u0131rmac\u0131lar\u0131n SARS-CoV-2 (yeni tip Koronavir\u00fcs), Alfa, Beta, Gama, Delta ve Omicron varyantlar\u0131, orijinal SARS vir\u00fcs\u00fc ve yarasa ve pangolinlerden bula\u015fan di\u011fer bir\u00e7ok hayvan Koronavir\u00fcs\u00fc dahil olmak \u00fczere birden fazla Koronavir\u00fcs\u00fc n\u00f6tralize edebilen alt\u0131 antikoru nas\u0131l elde ettiklerini a\u00e7\u0131klad\u0131. <\/p>\n\n\n\n
\u00c7al\u0131\u015fman\u0131n di\u011fer yazarlar\u0131ndan Chia Wan Ni, “\u00dc\u00e7 antikor, test edilen t\u00fcm SARS ile ilgili vir\u00fcsleri \u00e7ok d\u00fc\u015f\u00fck konsantrasyonlarda n\u00f6tralize ederek son derece geni\u015f ve g\u00fc\u00e7l\u00fc olarak \u00f6ne \u00e7\u0131kt\u0131.” dedi.<\/p>\n\n\n\n
“E7 B\u0130L\u0130NEN T\u00dcM KORONAV\u0130R\u00dcS VARYANTLARINI N\u00d6TRAL\u0130ZE ETT\u0130”<\/p>\n\n\n\n
E7 olarak adland\u0131r\u0131lan en g\u00fc\u00e7l\u00fc antikor hem SARS-CoV (SARS) hem de SARS-CoV-2 arbovir\u00fcslerini, hayvan arbovir\u00fcslerini ve Omicron XBB.1.16 gibi yeni ortaya \u00e7\u0131kan SARS-CoV-2 varyantlar\u0131n\u0131 n\u00f6tralize etti.<\/p>\n\n\n\n
E7 antikoru, Koronavir\u00fcs\u00fcn h\u00fccreleri istila etmek i\u00e7in kulland\u0131\u011f\u0131 ba\u015fak proteininin iki par\u00e7as\u0131n\u0131 k\u00f6pr\u00fcleyen benzersiz bir ba\u011flanma mekanizmas\u0131 yoluyla, vir\u00fcslerini etkisiz hale getirmeyi ba\u015fard\u0131. <\/p>\n\n\n\n
ANT\u0130KOR NASIL \u00c7ALI\u015eIYOR?<\/p>\n\n\n\n
Bu durum ba\u015fak proteinini inaktif bir konformasyonda kilitliyor ve vir\u00fcs\u00fcn h\u00fccreleri enfekte etmek ve hastal\u0131\u011fa neden olmak i\u00e7in ihtiya\u00e7 duydu\u011fu \u015fekil de\u011fi\u015ftirme s\u00fcrecini engelliyor.<\/p>\n\n\n\n
Chia, “E7 antikorunun n\u00f6tralize edici g\u00fcc\u00fc ve geni\u015fli\u011fi, kar\u015f\u0131la\u015ft\u0131\u011f\u0131m\u0131z di\u011fer SARS ile ilgili Koronavir\u00fcs antikorlar\u0131n\u0131 a\u015ft\u0131. Di\u011fer antikorlar\u0131n \u00e7o\u011fu etkinli\u011fini yitirirken, en yeni Omicron alt varyantlar\u0131na kar\u015f\u0131 bile etkinli\u011fini s\u00fcrd\u00fcrd\u00fc.” a\u00e7\u0131klamas\u0131n\u0131 yapt\u0131.<\/p>\n\n\n\n
“B\u0130R SONRAK\u0130 PANDEM\u0130Y\u0130 \u00d6NLEYEB\u0130L\u0130R”<\/p>\n\n\n\n
\u00d6te yandan, gelecekte ortaya \u00e7\u0131kacak Koronavir\u00fcsleri n\u00f6tralize etme potansiyeli y\u00fcksek olan E7 antikoru, bir sonraki pandeminin \u00f6nlenmesine yard\u0131mc\u0131 olabilir.<\/p>\n\n\n\n
Ara\u015ft\u0131rmac\u0131lar, antikorun mevcut ve gelecekteki Koronavir\u00fcslere kar\u015f\u0131 profilaktik (hastal\u0131k meydana gelmeden hastal\u0131\u011f\u0131n \u00f6nlenmesi) ve terap\u00f6tik (tedavi edici) bir ajan olarak potansiyelini daha fazla de\u011ferlendirmeyi planl\u0131yor.<\/p>","protected":false},"excerpt":{"rendered":"
Koronavir\u00fcs\u00fcn t\u00fcm varyantlar\u0131n\u0131 etkisiz hale getiren antikor ke\u015ffedildi D\u00fcnya genelinde yakla\u015f\u0131k 7 milyon insan\u0131n \u00f6l\u00fcm\u00fcne neden olan koronavir\u00fcs yak\u0131n bir zamanda tarih olabilir. Bilim insanlar\u0131, Omicron da dahil olmak \u00fczere yeni tip koronavir\u00fcs\u00fcn bilinen t\u00fcm varyantlar\u0131n\u0131 etkisiz hale getirebilen son derece g\u00fc\u00e7l\u00fc antikorlar ke\u015ffetti. Ara\u015ft\u0131rmac\u0131lar, bu antikorlar\u0131n koronavir\u00fcs\u00fcn yan\u0131 s\u0131ra, di\u011fer hayvan koronavir\u00fcsleri ile de […]<\/p>","protected":false},"author":1,"featured_media":6222,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[81],"tags":[100],"class_list":["post-15164","post","type-post","status-publish","format-standard","has-post-thumbnail","category-gundem","tag-koronavirus"],"yoast_head":"\n